Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.
In this timely volume, Drs. Dzau and Liew &; both pioneers in the area &; help cardiologists understand:
&; how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
&; what material has immediate relevance to the practicing clinician
&; how to incorporate genetics and genomics in your practice to ensure up-to-date patient care
The book opens with introductory chapters, then discusses:
&; cardiovascular single gene disorders
&; cardiovascular polygenic disorders
&; therapies and applications
Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
Recenzijos
"An excellent guide for developing, reviewing, or updating a keen understanding of genetics and its future in medicine. The book should find wide readership." Doodys Review
Contributors. Foreword. Introduction. 1 The gene in the twenty-first
century. Choong-Chin Liew, Victor J. Dzau. Part I: Cardiovascular single gene
disorders. 2 Monogenic hypercholesterolemia. Ruth McPherson. 3 Hypertrophic
cardiomyopathy. Ali J. Marian. 4 Dilated cardiomyopathy and other
cardiomyopathies. Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus. 5 The
long QT syndrome. Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima. Part
II: Cardiovascular polygenic disorders. 6 Atherosclerosis. Paivi Pajukanta,
Kiat Tsong Tan, Choong-Chin Liew. 7 Heart failure. Markus Meyer, Peter
VanBuren. 8 The implications of genes on the pathogenesis, diagnosis and
therapeutics of hypertension. Kiat Tsong Tan, Choong-Chin Liew. Part III:
Therapies and applications. 9 Gene therapy for cardiovascular disease:
inserting new genes, regulating the expression of native genes, and
correcting genetic defects. Ion S. Jovin, Frank J. Giordano. 10 Stem cell
therapy for cardiovascular disease. Emerson C. Perin, Guilherme V. Silva. 11
Pharmacogenetics and personalized medicine. Julie A. Johnson, Issam Zineh. 12
The potential of blood-based gene profiling for disease assessment. Steve
Mohr, Choong-Chin Liew. Index. Colour plates
Victor J. Dzau, MD James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA Choong-Chin Liew, PhD Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
