Dzau (medicine, Duke U.) and Liew (laboratory medicine and pathobiology, U. of Toronto, Canada) compile 12 chapters by medical specialists and researchers from North America and the UK who explain the concepts of cardiovascular genetic and genomics for cardiologists. First presented is a historic overview of genetics and genomics concepts and a specific application of blood-based microarray technology, and then they discuss single-gene and polygenic cardiovascular disorders. The final section addresses genetic and genomic-based therapeutics, such as stem cell therapy, pharmacogenics, and blood-based gene profiling. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)
Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.
In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand:
• how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
• what material has immediate relevance to the practicing clinician
• how to incorporate genetics and genomics in your practice to ensure up-to-date patient care
The book opens with introductory chapters, then discusses:
• cardiovascular single gene disorders
• cardiovascular polygenic disorders
• therapies and applications
Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
Recenzijos
"An excellent guide for developing, reviewing, or updating a keen understanding of genetics and its future in medicine. The book should find wide readership." Doodys Review
| Contributors |
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v | |
| Foreword |
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vii | |
| Introduction |
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ix | |
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The gene in the twenty-first century |
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1 | (18) |
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Part I Cardiovascular single gene disorders |
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Monogenic hypercholesterolemia |
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19 | (11) |
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Hypertrophic cardiomyopathy |
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30 | (25) |
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Dilated cardiomyopathy and other cardiomyopathies |
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55 | (28) |
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83 | (30) |
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Part II Cardiovascular polygenic disorders |
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113 | (24) |
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137 | (29) |
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The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension |
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166 | (29) |
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Part III Therapies and applications |
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Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects |
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195 | (30) |
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Stem cell therapy for cardiovascular disease |
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225 | (25) |
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Pharmacogenetics and personalized medicine |
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250 | (27) |
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The potential of blood-based gene profiling for disease assessment |
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277 | (24) |
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| Index |
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301 | |
Victor J. Dzau, MD James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA
Choong-Chin Liew, PhD Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
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