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xiii | |
Preface |
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xv | |
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1 An Overview of Toxicologic Pathology |
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1 | (2) |
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What Is Toxicologic Pathology? |
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3 | (1) |
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The Basis of Toxicologic Pathology |
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3 | (1) |
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The Challenges Facing Toxicologic Pathology |
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4 | (3) |
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Training and Certification in Toxicologic Pathology |
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7 | (1) |
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The "Practitioner" of Toxicologic Pathology |
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7 | (4) |
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11 | (1) |
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12 | (3) |
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PART I PRINCIPLES OF TOXICOLOGIC PATHOLOGY |
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2 Biochemical and Molecular Basis of Toxicity |
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15 | (1) |
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General Principles of Xenobiotic Disposition |
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16 | (9) |
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Interactions of Toxicants With Cellular and Molecular Targets |
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25 | (5) |
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Protective Mechanisms, Repair Mechanisms, and Adaptation |
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30 | (2) |
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32 | (1) |
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33 | (2) |
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3 Pharmacokinetics and Toxicokinetics |
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35 | (1) |
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Pharmacokinetics: Processes and Determinants |
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36 | (4) |
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Pharmacokinetic (Time-Course) Data and Derivation of Dose Metrics |
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40 | (1) |
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Pharmacokinetic Models and Computation of Dose Metrics |
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41 | (3) |
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Pharmacokinetics and Its Use in Designing Toxicity Studies |
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44 | (1) |
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45 | (1) |
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46 | (1) |
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4 Principles of Pharmacodynamics and Toxicodynamics |
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Introduction: Pharmacodynamics and Toxicodynamics Defined |
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47 | (1) |
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Relevance to Toxicological Pathology |
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48 | (1) |
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Drug/Toxin--Receptor Interactions Lead to Signal Transduction and Effect |
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48 | (6) |
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Selectivity and Safety: Therapeutic Versus Toxic Effect of Drugs |
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54 | (1) |
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Quantal Dose--Effect Curves |
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54 | (1) |
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Forms of Antagonism at the Tissue or Organism Level |
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55 | (1) |
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Dynamic Receptor Phenomena Resulting in Altered Efficacy Following Chronic Dosing |
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55 | (1) |
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Variation in Drug/Toxin Responsiveness |
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56 | (1) |
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Nonmonotonic Dose--Effect Curves |
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56 | (1) |
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Principles of Pharmacokinetic/Pharmacodynamic Modeling |
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57 | (1) |
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57 | (2) |
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5 Morphologic Manifestations of Toxic Cell Injury |
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59 | (7) |
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Irreversible versus Reversible Cell Injury |
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66 | (4) |
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70 | (10) |
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80 | (1) |
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81 | (2) |
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6 Carcinogenesis: Manifestation and Mechanisms |
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Overview of Carcinogenesis |
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83 | (5) |
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Mechanisms of Carcinogenesis |
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88 | (12) |
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100 | (1) |
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100 | (3) |
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103 | (1) |
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103 | (1) |
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104 | (2) |
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7 Design of Studies and Risk Management in Toxicologic Pathology: Addressing Risks in Product Discovery and Development |
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106 | (1) |
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Risk Assessment: The Process |
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106 | (2) |
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Risk Assessment: The Elements |
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108 | (2) |
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Toxicologic Pathology Issues in Risk Assessment |
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110 | (5) |
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Risk Perception and Acceptability |
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115 | (1) |
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116 | (2) |
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118 | (2) |
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Financial Risk and Toxicologic Pathology |
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120 | (1) |
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121 | (1) |
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122 | (1) |
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122 | (3) |
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PART II SYSTEMS TOXICOLOGIC PATHOLOGY |
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125 | (1) |
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Structure, Function, and Cell Biology |
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126 | (2) |
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Evaluation of Liver Toxicity |
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128 | (2) |
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130 | (18) |
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Mechanisms of Toxicity in Liver |
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148 | (3) |
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151 | (1) |
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151 | (2) |
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153 | (1) |
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154 | (28) |
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182 | (11) |
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193 | (1) |
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194 | (2) |
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10 Skeletal Muscle System |
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196 | (3) |
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Evaluation of Skeletal Muscle Toxicity |
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199 | (2) |
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201 | (3) |
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204 | (8) |
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212 | (1) |
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212 | (1) |
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213 | (1) |
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213 | (1) |
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Structure and Function of the Kidney |
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214 | (5) |
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Evaluation of Renal Toxicity |
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219 | (13) |
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232 | (6) |
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Mechanisms of Renal Toxicity |
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238 | (26) |
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Part 2 Lower Urinary Tract |
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264 | (1) |
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264 | (1) |
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Structure and Function of Lower Urinary Tract |
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264 | (1) |
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Mechanisms of Lower Urinary Tract Toxicity |
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265 | (2) |
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Lower Urinary Tract Response to Injury |
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267 | (2) |
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Evaluation of Lower Urinary Tract Toxicity |
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269 | (2) |
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271 | (1) |
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271 | (2) |
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273 | (16) |
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Mechanisms and Evaluation of Toxicity |
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289 | (7) |
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296 | (16) |
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312 | (1) |
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313 | (2) |
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315 | (2) |
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Phylogenesis and Ontogenesis |
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317 | (1) |
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Structure, Function, and Cell Biology |
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318 | (5) |
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Evaluation of Hematotoxicity |
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323 | (2) |
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325 | (13) |
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Responses of Hematopoietic Tissues to Injury |
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338 | (11) |
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349 | (1) |
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349 | (2) |
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351 | (1) |
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Structure, Function, and Cell Biology |
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352 | (11) |
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363 | (4) |
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367 | (19) |
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386 | (6) |
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392 | (1) |
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393 | (1) |
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393 | (2) |
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395 | (1) |
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Structure and Function of the Gastrointestinal Tract |
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396 | (15) |
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Evaluation of Gastrointestinal Toxicity |
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411 | (7) |
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Response of the Gastrointestinal Tract to Injury |
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418 | (13) |
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Mechanisms of Gastrointestinal Toxicity |
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431 | (10) |
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441 | (1) |
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441 | (2) |
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443 | (1) |
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Normal Structure and Function of the Exocrine Pancreas |
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444 | (1) |
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445 | (3) |
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Responses of Exocrine Pancreas to Injury |
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448 | (6) |
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Mechanisms of Exocrine Pancreatic Toxicity |
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454 | (3) |
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457 | (1) |
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458 | (1) |
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17 Male Reproductive System |
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459 | (1) |
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Structure, Function, and Cell Biology |
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460 | (15) |
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475 | (10) |
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485 | (16) |
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501 | (15) |
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516 | (1) |
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18 Female Reproductive System |
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517 | (1) |
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Structure, Function, and Cell Biology |
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518 | (16) |
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Evaluation of Female Reproductive System Toxicity |
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534 | (4) |
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Mechanisms of Toxicity in the Female Reproductive System |
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538 | (6) |
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Carcinogenesis in the Female Reproductive System |
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544 | (1) |
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545 | (2) |
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547 | (1) |
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Mammary Gland Structure and Function |
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548 | (5) |
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553 | (2) |
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555 | (2) |
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557 | (4) |
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561 | (1) |
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562 | (1) |
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562 | (4) |
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566 | (1) |
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567 | (1) |
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567 | (4) |
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571 | (2) |
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573 | (6) |
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579 | (2) |
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581 | (1) |
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581 | (2) |
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583 | (1) |
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583 | (2) |
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585 | (1) |
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586 | (1) |
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586 | (1) |
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587 | (1) |
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588 | (2) |
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590 | (1) |
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591 | (1) |
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591 | (1) |
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591 | (3) |
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594 | (1) |
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Part 5 Thyroid Follicular Cells |
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594 | (1) |
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594 | (4) |
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598 | (2) |
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600 | (4) |
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604 | (4) |
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608 | (1) |
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608 | (1) |
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609 | (3) |
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612 | (1) |
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Response of Parathyroid Chief Cells to Injury |
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613 | (2) |
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615 | (3) |
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Part 7 Endocrine Pancreas |
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618 | (1) |
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618 | (1) |
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618 | (1) |
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619 | (1) |
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619 | (3) |
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622 | (1) |
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622 | (1) |
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623 | (1) |
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623 | (2) |
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625 | (3) |
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Neuroanatomic Considerations in Toxicologic Neuropathology |
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628 | (3) |
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Evaluation of Neurotoxicity |
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631 | (17) |
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Nervous System Responses to Neurotoxic Injury |
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648 | (18) |
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Mechanisms of Nervous System Injury |
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666 | (5) |
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671 | (1) |
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672 | (2) |
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Chapter 22a Special Senses---Eye |
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674 | (55) |
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674 | (1) |
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674 | (18) |
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692 | (6) |
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Response to Injury by Specific Ocular Tissues |
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698 | (17) |
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Mechanisms of Ocular Toxicity |
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715 | (13) |
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728 | (1) |
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729 | (1) |
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Chapter 22b Special Senses---Ear |
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729 | (20) |
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729 | (1) |
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730 | (4) |
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Testing for Otic Toxicity |
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734 | (1) |
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Responses to Injury and Mechanisms of Injury |
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735 | (12) |
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747 | (1) |
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747 | (2) |
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749 | (2) |
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Structure, Function, and Cell Biology of Bone and Cartilage |
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751 | (7) |
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758 | (9) |
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767 | (11) |
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778 | (12) |
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790 | (1) |
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790 | (1) |
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24 The Integumentary System |
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791 | (1) |
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791 | (10) |
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801 | (9) |
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810 | (12) |
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822 | (1) |
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822 | (1) |
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25 Embryo, Fetus, and Placenta |
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823 | (1) |
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Normal Morphologic Development |
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824 | (1) |
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Developmental Toxicity Testing and Risk Assessment |
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825 | (6) |
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831 | (15) |
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Principles of Developmental Toxicity |
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846 | (3) |
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Mechanisms of Developmental Toxicity |
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849 | (4) |
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853 | (1) |
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853 | (2) |
Index |
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