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Fundamentals of Toxicologic Pathology 3rd edition [Kietas viršelis]

Edited by (Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA), Edited by , Edited by (Profess), Edited by (President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA)
  • Formatas: Hardback, 902 pages, aukštis x plotis: 276x216 mm, weight: 2650 g
  • Išleidimo metai: 06-Dec-2017
  • Leidėjas: Academic Press Inc
  • ISBN-10: 0128098414
  • ISBN-13: 9780128098417
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 902 pages, aukštis x plotis: 276x216 mm, weight: 2650 g
  • Išleidimo metai: 06-Dec-2017
  • Leidėjas: Academic Press Inc
  • ISBN-10: 0128098414
  • ISBN-13: 9780128098417
Kitos knygos pagal šią temą:

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.

The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

  • Presents revised and updated information for each chapter on systems
  • Contains expanded sections on applied toxicologic pathology
  • Includes the essential information necessary to understand toxicologic pathology in an accessible language

Daugiau informacijos

Presents a revised and updated edition of the classic reference on toxicologic pathology systems approach
List of Contributors
xiii
Preface xv
1 An Overview of Toxicologic Pathology
Colin G. Rousseaux
Matthew A. Wallig
Wanda M. Haschek
Brad Bolon
Introduction
1(2)
What Is Toxicologic Pathology?
3(1)
The Basis of Toxicologic Pathology
3(1)
The Challenges Facing Toxicologic Pathology
4(3)
Training and Certification in Toxicologic Pathology
7(1)
The "Practitioner" of Toxicologic Pathology
7(4)
Summary
11(1)
Further Reading
12(3)
PART I PRINCIPLES OF TOXICOLOGIC PATHOLOGY
2 Biochemical and Molecular Basis of Toxicity
Lois D. Lehman-Mckeeman
Stefan U. Ruepp
Introduction
15(1)
General Principles of Xenobiotic Disposition
16(9)
Interactions of Toxicants With Cellular and Molecular Targets
25(5)
Protective Mechanisms, Repair Mechanisms, and Adaptation
30(2)
Summary
32(1)
Further Reading
33(2)
3 Pharmacokinetics and Toxicokinetics
Kannan Krishnan
Sandrine F. Chebekoue
Introduction
35(1)
Pharmacokinetics: Processes and Determinants
36(4)
Pharmacokinetic (Time-Course) Data and Derivation of Dose Metrics
40(1)
Pharmacokinetic Models and Computation of Dose Metrics
41(3)
Pharmacokinetics and Its Use in Designing Toxicity Studies
44(1)
Concluding Remarks
45(1)
Further Reading
46(1)
4 Principles of Pharmacodynamics and Toxicodynamics
Duncan C. Ferguson
Introduction: Pharmacodynamics and Toxicodynamics Defined
47(1)
Relevance to Toxicological Pathology
48(1)
Drug/Toxin--Receptor Interactions Lead to Signal Transduction and Effect
48(6)
Selectivity and Safety: Therapeutic Versus Toxic Effect of Drugs
54(1)
Quantal Dose--Effect Curves
54(1)
Forms of Antagonism at the Tissue or Organism Level
55(1)
Dynamic Receptor Phenomena Resulting in Altered Efficacy Following Chronic Dosing
55(1)
Variation in Drug/Toxin Responsiveness
56(1)
Nonmonotonic Dose--Effect Curves
56(1)
Principles of Pharmacokinetic/Pharmacodynamic Modeling
57(1)
Further Reading
57(2)
5 Morphologic Manifestations of Toxic Cell Injury
Matthew A. Wallig
Evan B. Janovitz
Introduction
59(7)
Irreversible versus Reversible Cell Injury
66(4)
Irreversible Cell Injury
70(10)
Summary
80(1)
Further Readings
81(2)
6 Carcinogenesis: Manifestation and Mechanisms
David E. Malarkey
Mark J. Hoenerhoff
Robert R. Maronpot
Overview of Carcinogenesis
83(5)
Mechanisms of Carcinogenesis
88(12)
Summary
100(1)
Identifying Carcinogens
100(3)
Overall Summary
103(1)
Acknowledgments
103(1)
Further Reading
104(2)
7 Design of Studies and Risk Management in Toxicologic Pathology: Addressing Risks in Product Discovery and Development
Ricardo Ochoa
Introduction
106(1)
Risk Assessment: The Process
106(2)
Risk Assessment: The Elements
108(2)
Toxicologic Pathology Issues in Risk Assessment
110(5)
Risk Perception and Acceptability
115(1)
Risk Communication
116(2)
Risk Management
118(2)
Financial Risk and Toxicologic Pathology
120(1)
Summary
121(1)
Acknowledgments
122(1)
Further Reading
122(3)
PART II SYSTEMS TOXICOLOGIC PATHOLOGY
8 Liver and Gall Bladder
Russell C. Cattley
John M. Cullen
Introduction
125(1)
Structure, Function, and Cell Biology
126(2)
Evaluation of Liver Toxicity
128(2)
Response to Injury
130(18)
Mechanisms of Toxicity in Liver
148(3)
Summary
151(1)
Further Reading
151(2)
9 Cardiovascular System
Brian R. Berridge
John F. Van Vleet
Eugene Herman
Introduction
153(1)
Heart
154(28)
Blood Vessels
182(11)
Summary
193(1)
Further Reading
194(2)
10 Skeletal Muscle System
Brian R. Berridge
Brad Bolon
Eugene Herman
Structure and Function
196(3)
Evaluation of Skeletal Muscle Toxicity
199(2)
Response to Injury
201(3)
Mechanisms of Toxicity
204(8)
Summary
212(1)
Further Reading
212(1)
11 Urinary System
Kanwar N.M. Khan
Gordon C. Hard
Xiantang Li
Carl L. Alden
Part 1 Kidney
213(1)
Introduction
213(1)
†In Memoriam
Structure and Function of the Kidney
214(5)
Evaluation of Renal Toxicity
219(13)
Response to Renal Injury
232(6)
Mechanisms of Renal Toxicity
238(26)
Part 2 Lower Urinary Tract
264(1)
Introduction
264(1)
Structure and Function of Lower Urinary Tract
264(1)
Mechanisms of Lower Urinary Tract Toxicity
265(2)
Lower Urinary Tract Response to Injury
267(2)
Evaluation of Lower Urinary Tract Toxicity
269(2)
Acknowledgments
271(1)
Further Reading
271(2)
12 Immune System
Christine Ruehl-Fehlert
George A. Parker
Susan A. Elmore
C. Frieke Kuper
Introduction
273(16)
Mechanisms and Evaluation of Toxicity
289(7)
Response to Injury
296(16)
Summary
312(1)
Further Reading
313(2)
13 Hematopoietic System
Lila Ramaiah
Denise I. Bounous
Susan A. Elmore
Introduction
315(2)
Phylogenesis and Ontogenesis
317(1)
Structure, Function, and Cell Biology
318(5)
Evaluation of Hematotoxicity
323(2)
Mechanisms of Toxicity
325(13)
Responses of Hematopoietic Tissues to Injury
338(11)
Summary
349(1)
Further Reading
349(2)
14 Respiratory System
Jack R. Harkema
Kristen J. Nikula
Wanda M. Haschek
Introduction
351(1)
Structure, Function, and Cell Biology
352(11)
Testing for Toxicity
363(4)
Response to Injury
367(19)
Mechanisms of Toxicity
386(6)
Summary
392(1)
Acknowledgment
393(1)
Further Reading
393(2)
15 Digestive System
Matthew A. Wallig
Introduction
395(1)
Structure and Function of the Gastrointestinal Tract
396(15)
Evaluation of Gastrointestinal Toxicity
411(7)
Response of the Gastrointestinal Tract to Injury
418(13)
Mechanisms of Gastrointestinal Toxicity
431(10)
Summary
441(1)
Further Reading
441(2)
16 Exocrine Pancreas
Matthew A. Wallig
John M. Sullivan
Introduction
443(1)
Normal Structure and Function of the Exocrine Pancreas
444(1)
Evaluation of Toxicity
445(3)
Responses of Exocrine Pancreas to Injury
448(6)
Mechanisms of Exocrine Pancreatic Toxicity
454(3)
Summary
457(1)
Further Reading
458(1)
17 Male Reproductive System
Dianne M. Creasy
Robert E. Chapin
Introduction
459(1)
Structure, Function, and Cell Biology
460(15)
Evaluation of Toxicity
475(10)
Response to Injury
485(16)
Mechanisms of Toxicity
501(15)
Further Reading
516(1)
18 Female Reproductive System
Daniel G. Rudmann
George L. Foley
Introduction
517(1)
Structure, Function, and Cell Biology
518(16)
Evaluation of Female Reproductive System Toxicity
534(4)
Mechanisms of Toxicity in the Female Reproductive System
538(6)
Carcinogenesis in the Female Reproductive System
544(1)
Further Reading
545(2)
19 The Mammary Gland
Barbara Davis
Suzanne E. Fenton
Introduction
547(1)
Mammary Gland Structure and Function
548(5)
Morphologic Evaluation
553(2)
Evaluation of Toxicity
555(2)
Response to Injury
557(4)
Mechanisms of Toxicity
561(1)
Summary
562(1)
Further Reading
562(4)
20 Endocrine System
Matthew A. Wallig
Introduction
566(1)
Part 1 Adrenal Cortex
567(1)
Structure and Function
567(4)
Evaluation of Toxicity
571(2)
Response to Injury
573(6)
Mechanisms of Toxicity
579(2)
Part 2 Adrenal Medulla
581(1)
Structure and Function
581(2)
Testing for Toxicity
583(1)
Response to Injury
583(2)
Mechanisms of Toxicity
585(1)
Part 3 Pituitary Gland
586(1)
Structure and Function
586(1)
Evaluation of Toxicity
587(1)
Response to Injury
588(2)
Mechanisms of Toxicity
590(1)
Part 4 Thyroid C Cells
591(1)
Structure and Function
591(1)
Response to Injury
591(3)
Mechanisms of Toxicity
594(1)
Part 5 Thyroid Follicular Cells
594(1)
Structure and Function
594(4)
Evaluation of Toxicity
598(2)
Response to Injury
600(4)
Mechanisms of Toxicity
604(4)
Part 6 Parathyroid Gland
608(1)
Introduction
608(1)
Structure and Function
609(3)
Evaluation of Toxicity
612(1)
Response of Parathyroid Chief Cells to Injury
613(2)
Mechanisms of Toxicity
615(3)
Part 7 Endocrine Pancreas
618(1)
Introduction
618(1)
Structure and Function
618(1)
Evaluation of Toxicity
619(1)
Response to Injury
619(3)
Mechanisms of Toxicity
622(1)
Summary
622(1)
Acknowledgments
623(1)
Further Reading
623(2)
21 Nervous System
Brad Bolon
Robert H. Garman
Mark T. Butt
David C. Dorman
Introduction
625(3)
Neuroanatomic Considerations in Toxicologic Neuropathology
628(3)
Evaluation of Neurotoxicity
631(17)
Nervous System Responses to Neurotoxic Injury
648(18)
Mechanisms of Nervous System Injury
666(5)
Summary
671(1)
Further Reading
672(2)
22 Special Senses
Chapter 22a Special Senses---Eye
674(55)
Leandro Teixeira
Richard R. Dubielzig
Introduction
674(1)
Structure and Function
674(18)
Evaluation of Toxicity
692(6)
Response to Injury by Specific Ocular Tissues
698(17)
Mechanisms of Ocular Toxicity
715(13)
Summary
728(1)
Further Reading
729(1)
Chapter 22b Special Senses---Ear
729(20)
Kenneth A. Schafer
Brad Bolon
Introduction
729(1)
Structure and Function
730(4)
Testing for Otic Toxicity
734(1)
Responses to Injury and Mechanisms of Injury
735(12)
Summary
747(1)
Further Reading
747(2)
23 Bone and Joints
Diane Gunson
Kathryn E. Gropp
Aurore Varela
Introduction
749(2)
Structure, Function, and Cell Biology of Bone and Cartilage
751(7)
Evaluation of Toxicity
758(9)
Responses to Injury
767(11)
Mechanisms of Toxicity
778(12)
Summary
790(1)
Further Reading
790(1)
24 The Integumentary System
Kelly L. Diegel
Dimitry M. Danilenko
Zbigniew W. Wojcinski
Introduction
791(1)
Structure and Function
791(10)
Response to Injury
801(9)
Mechanisms of Toxicity
810(12)
Summary
822(1)
Further Reading
822(1)
25 Embryo, Fetus, and Placenta
Colin G. Rousseaux
Brad Bolon
Introduction
823(1)
Normal Morphologic Development
824(1)
Developmental Toxicity Testing and Risk Assessment
825(6)
Responses to Injury
831(15)
Principles of Developmental Toxicity
846(3)
Mechanisms of Developmental Toxicity
849(4)
Summary
853(1)
Further Reading
853(2)
Index 855
Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseauxs Handbook of Toxicologic Pathology. Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [ sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseauxs Handbook of Toxicologic Pathology. Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicologys Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPAs FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathologys Achievement Award in 2007 and the Midwest Regional Chapter Society of Toxicologys Kenneth DuBois Award in 2011. Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseauxs Handbook of Toxicologic Pathology.