Main topics covered:B-Cell Development; Immunoglobulin Gene Rearrangement;Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli-cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa-ted Lymphomas; Oncogenes and Transcriptional Factors(text to follow)
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B-Cell Development.- Progenitor and Precursor B Lymphocytes of Mice.
Proliferation and Differentiation In Vitro and Population, Differentiation
and Turnover in SCID Mice In Vivo of Normal and Abnormal Cells.- Isolation
and Characterization of a Stromal Cell Line.- Growth and Differentiation of a
Bipotent Precursor of B Cells and Macrophages.- Control of Intramarrow B-Cell
Genesis by Stromal Cell-Derived Molecules.- Establishment of a Reproducible
Culture Technique for the Selective Growth of B-Cell Progenitors.- Multiple
Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone
Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and
Stromal Cell Interactions.- The Purification of B-Cell Precursors From Mouse
Fetal Liver.- BCR/ABL Enhances Growth of Multipotent Progenitor Cells But
Does Not Block Their Differentiation Potential In Vitro.- Repopulation of
SCID Mice with Fetal-Derived B-Lineage Cells.- Early B-Cell Repertoires.- In
Vitro Growth and Maturation of Human B-Cell Precursors.- Modulation of Signal
Transduction in Phosphocholine-Specific B cells from ?? Transgenic Mice.-
Immunoglobulin Gene Rearrangement.- Activities Involved in V(D)J
Recombination.- Double-Strand Breaks Associated with V(D)J Recombination at
the TCR? Locus in Murine Thymocytes.- Replication, Transcription, CpG
Methylation and DNA Topology in V(D)J Recombination.- Rearrangement and
Expression of Immunoglobulin Genes in Transgenic Mice.- Regulation of Switch
Recombination to the Murine ? 1 Gene.- Protein Recognition Motifs of S? 3 DNA
Are Statistically Correlated with Switch Recombination Breakpoints.-
Regulation of Transcription of the Germline Immunoglobulin ? Constant Region
Gene.- S?BP/BSAP/NF-S? B1, a Murine and Human B-Cell Stage Specific
NuclearFactor with DNA Binding Specificity Implying Roles in
Switch-Recombination and Transcription.- Multiple Myeloma, Plasmacytomas.-
Multidrug Resistance of a Continuously Differentiating Monoclonal B Lineage
in the Blood and Bone Marrow of Patients with Multiple Myeloma.- Expression
of Multiple Adhesion Molecules on Circulating Monoclonal B Cells in Myeloma.-
Circulating Peripheral Blood Plasma Cells in Multiple Myeloma.- Circulating B
Lymphocytes in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven
Pre-Myeloma Cell Population.- In Which Cells Does Neoplastic Transformation
Occur in Myelomatosis?.- Differential Expression of c-myc-mRNA and
c-MYC-Protein During Terminal Neoplastic B-Cell Differentiation.- Genes
Expressed Selectively in Plasmacytomas: Markers of Differentiation and
Transformation.- PCS, a Gene Related to the Immunoglobulin Super Family of
Axonal Glycoproteins is Expressed in Murine Plasma Cell Tumors.- Inhibiting
IL-6 in Human Multiple Myeloma.- Pathophysiology of Human Multiple Myeloma-
Recent Advances and Future Directions.- An Exceptional Mouse Plasmacytoma
with a New Kappa/N-myc [ T(6; 12) (C1 ; B)] Translocation Expresses N-myc But
Not c-myc.- Experimental Model of Human Light-Chain-Associated Disease.-
Lymphomas: B-CLL, Follicular Lymphomas BCL-2, BCL-1.- On the Role of
Endogenously Produced TNF-? and IL-6 as Regulators of Growth and
Differentiation of B-Type Chronic Lymphocytic Leukemia Cells in Vitro.- BCL-2
in B-Chronic Lymphocytic Leukemia.- Subcellular Localization of BCL-2
Protein.- Collaboration of PIM-1 and BCL-2 in Lymphomagenesis.- The Role of
bcl-2 in Lymphoid Differentiation and Neoplastic Transformation.- Evolution
of Leukemic Heterogeneity of Human B-CLL Lymphocytes Between and Within
Patients.- p53 Mutations in B-Cell ChronicLymphocytic Leukemia.- Burkitts
Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements.- Centrocytic
Lymphoma: a B-Cell Non-Hodgkins Lymphoma Characterized by Chromosome 11
BCL-1 and PRAD 1 Rearrangements.- Two Surface Antigen Targets for
Immunotoxin-Mediated Elimination of Normal and Neoplastic Murine B Cells.-
Generation and Differentiation Potential of Retrovirus-lmmortalized Mature
Murine B Cells.- The Role of Growth Factors in Human Lymphomas.- Production
of Interleukin-6 in High Grade B Lymphomas.- Lymphomas: EBV, AIDS Associated
Lymphomas.- Mutational Analysis of the Transforming Function of the EBV
Encoded LMP-1.- Integration of EBV in Burkitts Lymphoma Cells.- The
Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic
Mice.- AIDS Associated Non-Hodgkins Lymphomas Represent a Broad Spectrum of
Monoclonal and Polyclonal Lymphoproliferative Processes.- Lymphomas in Mice
with Retrovirus-lnduced Immunodeficiency.- Does HIV Infection of B
Lymphocytes Initiate AIDS Lymphoma? Detection by PCR of Viral Sequences in
Lymphoma Tissue.- Oncogenes and Transcriptional Factors.- Lymphocyte
Activation and the Family of NF-?B Transcription Factor Complexes.-
Transactivation of the c-myc Gene by HTLV-1 tax is Mediated by NF-?B.-
Cloning and Characterization of DNA Binding Factors Which Bind Sequences
Required for Proper c-myc Initiation.- Transcriptional Activities of the Myc
and Max Proteins in Mammalian Cells.- c-myc Transactivates the Ornithine
Decarboxylase Gene.- v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence:
v-Raf Suppresses Apoptosis.- Cyclins in the Cell Cycle: An Overview.- The
Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis
and Transformation.- V-rel and C-rel Modulate the Expression of BothBursal
and Non-Bursal Antigens on Avian B-Cell Lymphomas.- Why Dont Germline
Mutations in RB1 Predispose to Leukemia?.- Loss of p53 Expression in
Myc-induced B Lineage Tumors.