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Metallic Biomaterials: New Directions and Technologies [Kietas viršelis]

  • Formatas: Hardback, 328 pages, aukštis x plotis x storis: 249x175x20 mm, weight: 862 g
  • Išleidimo metai: 12-Apr-2017
  • Leidėjas: Blackwell Verlag GmbH
  • ISBN-10: 3527341269
  • ISBN-13: 9783527341269
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 328 pages, aukštis x plotis x storis: 249x175x20 mm, weight: 862 g
  • Išleidimo metai: 12-Apr-2017
  • Leidėjas: Blackwell Verlag GmbH
  • ISBN-10: 3527341269
  • ISBN-13: 9783527341269
Kitos knygos pagal šią temą:
With its comprehensive coverage of recent progress in metallic biomaterials, this reference focuses on emerging materials and new biofunctions for promising applications.
The text is systematically structured, with the information organized according to different material systems, and concentrates on various advanced materials, such as anti-bacterial functionalized stainless steel, biodegradable metals with bioactivity, and novel structured metallic biomaterials. Authors from well-known academic institutes and with many years of clinical experience discuss all important aspects, including design strategies, fabrication and modification techniques, and biocompatibility.
Preface xi
About the Authors xiii
1 Introduction 1(30)
1.1 Traditional Metallic Biomaterials
1(2)
1.2 Revolutionizing Metallic Biomaterials and Their New Biofunctions
3(7)
1.2.1 What are Revolutionizing Metallic Biomaterials?
3(1)
1.2.2 Antibacterial Function
3(2)
1.2.3 Promotion of Osteogenesis
5(3)
1.2.4 Reduction of In-stent Restenosis
8(1)
1.2.5 MRI Compatibility
9(1)
1.2.6 Radiopacity
10(1)
1.2.7 Self-Adjustment of Young's Modulus for Spinal Fixation Applications
10(1)
1.3 Technical Consideration on Alloying Design of Revolutionizing Metallic Biomaterials
10(6)
1.3.1 Evolution of Mechanical Properties with Implantation Time
10(4)
1.3.2 Biocorrosion or Biodegradation Behavior and Control on Ion Release
14(2)
1.4 Novel Process Technologies for Revolutionizing Metallic Biomaterials
16(4)
1.4.1 3D Printing
17(1)
1.4.2 Safety and Effectiveness of Biofunctions
17(3)
1.4.3 Severe Plastic Deformation
20(1)
References
20(11)
2 Introduction of the Biofunctions into Traditional Metallic Biomaterials 31(28)
2.1 Antibacterial Metallic Biomaterials
31(9)
2.1.1 Antibacterial Metals
31(2)
2.1.2 Antibacterial Stainless Steels
33(4)
2.1.2.1 Ag-Bearing Antibacterial Stainless Steels
33(1)
2.1.2.2 Cu-Bearing Antibacterial Stainless Steels
34(2)
2.1.2.3 Other Antibacterial Stainless Steels
36(1)
2.1.3 Antibacterial Ti Alloys
37(2)
2.1.3.1 Antibacterial Ti-Ag Alloys
37(1)
2.1.3.2 Antibacterial Ti-Cu Alloys
37(1)
2.1.3.3 Antibacterial TiNi-Based Alloys
38(1)
2.1.3.4 Surface-Modified Ti Alloys with Antibacterial Property
38(1)
2.1.4 Antibacterial Mg Alloys
39(1)
2.1.5 Antibacterial Bulk Metallic Glasses
40(1)
2.2 MRI Compatibility of Metallic Biomaterials
40(7)
2.2.1 MRI Compatibility of Traditional Metallic Biomaterials
44(1)
2.2.2 MRI-Compatible Zr Alloys
44(2)
2.2.3 MRI-Compatible Nb Alloys
46(1)
2.2.4 Other MRI-Compatible Alloys
47(1)
2.3 Radiopacity of Metallic Biomaterials
47(3)
2.3.1 Stainless Steel Stents
48(1)
2.3.2 Co-Cr Stents
48(1)
2.3.3 Nitinol Stents
49(1)
2.3.4 Ta Stents
49(1)
2.3.5 Other Metallic Stents
49(1)
References
50(9)
3 Development of Mg-Based Degradable Metallic Biomaterials 59(54)
3.1 Background
59(1)
3.2 Mg-Based Alloy Design and Selection Considerations
60(23)
3.2.1 Biodegradation
60(4)
3.2.2 Biocompatibility
64(1)
3.2.3 Considerations in Mg-Based Alloy Design
64(3)
3.2.3.1 Mechanical Property Requirements
64(1)
3.2.3.2 Material Compositional Design
65(1)
3.2.3.3 Toxicity and Degradation Consideration
66(1)
3.2.4 Methods to Improve Mechanical Property
67(16)
3.2.4.1 In Situ Strengthening
67(8)
3.2.4.2 Post-processing
75(8)
3.3 State of the Art of the Mg-Based Alloy Material Research
83(9)
3.3.1 Pure Mg
83(1)
3.3.2 Mg-Based Alloys with Essential Elements
84(2)
3.3.2.1 Mg-Ca-Based Alloys
84(1)
3.3.2.2 Mg-Si- and Mg-Sr-Based Alloys
85(1)
3.3.3 Mg-Based Alloys with High Strength
86(2)
3.3.3.1 Mg-Zn-Based Alloys
87(1)
3.3.3.2 Mg-RE-Based Alloys
87(1)
3.3.4 Mg-Based Alloys with Special Biofunctions
88(2)
3.3.5 Mg-Based Alloys with Improved Corrosion Resistance
90(1)
3.3.6 Mg-Based Alloys with Bioactive Surfaces
91(1)
3.3.6.1 Drug-Releasing Coatings
91(1)
3.3.6.2 Biomimetic Coatings
91(1)
3.4 State of the Art of Medical Mg-Based Alloy Device Research
92(5)
3.4.1 Cardiovascular Devices
92(2)
3.4.2 Orthopedic Devices
94(3)
3.5 Challenges and Opportunities for Mg-Based Biomedical Materials and Devices
97(1)
References
98(15)
4 Development of Fe-Based Degradable Metallic Biomaterials 113(48)
4.1 Background
113(1)
4.2 Pure Iron
114(13)
4.2.1 Mechanical Properties of Pure Iron
114(1)
4.2.2 Metabolism and Toxicity of Pure Iron
114(4)
4.2.2.1 The Distribution of Iron in Human Body
114(1)
4.2.2.2 Physiological Function of Iron in Human Body
114(1)
4.2.2.3 Iron Absorption
114(3)
4.2.2.4 The Maintenance of Iron Balance
117(1)
4.2.2.5 The Toxicity of Iron
118(1)
4.2.3 Basic Properties of Pure Iron
118(1)
4.2.3.1 Effects of Processing Technologies on the Microstructure of Pure Iron
118(1)
4.2.4 Degradation Behavior of Pure Iron in the Physiological Environment
119(2)
4.2.5 In Vitro Experiments of Pure Iron
121(2)
4.2.6 In Vivo Experiments of Pure Iron
123(4)
4.3 Iron Alloys
127(12)
4.4 Iron-Based Composites
139(5)
4.4.1 Compositing with Metals
139(2)
4.4.2 Compositing with Nonmetallic Materials
141(1)
4.4.3 In Vitro Biocompatibility of Iron-Based Composites
142(2)
4.5 Surface Modification of Iron-Based Materials
144(6)
4.5.1 Surface Modification for Improving Biocompatibility
144(3)
4.5.2 Surface Modification for Regulating Degradation Behavior
147(3)
4.6 New Fabrication Technologies for Iron-Based Materials
150(4)
4.6.1 Electroforming
150(1)
4.6.2 Equal Channel Angular Pressing
150(1)
4.6.3 Metal Injection Molding
151(1)
4.6.4 Cold Gas Dynamic Spraying
151(2)
4.6.5 3D Printing
153(1)
4.7 Outlook
154(2)
References
156(5)
5 Development of Zn-Based Degradable Metallic Biomaterials 161(28)
5.1 Backgrounds
161(1)
5.2 Body Zn Distribution and Mobilization
162(1)
5.3 The Physiological Function of Zn
162(2)
5.4 State of the Art of the Zn-Based Alloy Material Research
164(18)
5.4.1 Pure Zn
164(1)
5.4.2 Binary Zn-Based Alloys
165(9)
5.4.2.1 The Microstructure of Binary Zn-Based Alloy
166(1)
5.4.2.2 The Mechanical Properties of Binary Zn-Based Alloy
167(1)
5.4.2.3 The Degradation Behavior of Binary Zn-Based Alloys
167(3)
5.4.2.4 The Biocompatibility of Binary Zn-Based Alloys
170(4)
5.4.3 Ternary Zn-Based Alloys
174(4)
5.4.3.1 The Microstructure of Ternary Zn-Based Alloys
174(1)
5.4.3.2 The Mechanical Properties of Ternary Zn-Based Alloys
175(1)
5.4.3.3 The Degradation Behavior of Ternary Zn-Based Alloys
176(2)
5.4.3.4 The Biocompatibility of Ternary Zn-Based Alloys
178(1)
5.4.4 Zn-Based Composites
178(11)
5.4.4.1 Zn-ZnO Composites
178(4)
5.4.4.2 Zn-Nanodiamond Composites
182(1)
5.5 Challenges and Opportunities for Zn-Based Biomedical Materials and Devices
182(3)
References
185(4)
6 Development of Bulk Metallic Glasses for Biomedical Application 189(34)
6.1 Background
189(7)
6.1.1 Oxide Glasses as Biomaterials
189(2)
6.1.2 Bulk Metallic Glasses
191(1)
6.1.3 Fabrication of Bulk Metallic Glasses
191(2)
6.1.4 Properties of Bulk Metallic Glasses
193(3)
6.2 Nonbiodegradable Bulk Metallic Glasses
196(6)
6.2.1 Ti-Based Bulk Metallic Glasses
197(1)
6.2.2 Zr-Based Bulk Metallic Glasses
198(3)
6.2.3 Fe-Based Bulk Metallic Glasses
201(1)
6.3 Biodegradable Bulk Metallic Glasses
202(7)
6.3.1 Mg-Based Bulk Metallic Glasses
202(5)
6.3.2 Ca-Based Bulk Metallic Glasses
207(1)
6.3.3 Zn-Based Bulk Metallic Glasses
208(1)
6.3.4 Sr-Based Bulk Metallic Glasses
209(1)
6.4 Perspectives on Future R&D of Bulk Metallic Glass for Biomedical Application
209(4)
6.4.1 How to Design Better Bulk Metallic Glasses
209(2)
6.4.1.1 Functional Minor Alloying Elements
209(1)
6.4.1.2 The Glass-Forming Ability
210(1)
6.4.2 Surface Modification of Bulk Metallic Glasses
211(1)
6.4.3 How to Manufacture Medical Devices Using Bulk Metallic Glasses
211(1)
6.4.4 Future Biomedical Application Areas of Bulk Metallic Glass
211(2)
References
213(10)
7 Development of Bulk Nanostructured Metallic Biomaterials 223(32)
7.1 Background
223(7)
7.1.1 Processing Methods
224(1)
7.1.2 Property Variation
225(3)
7.1.3 Structure-Property Relationship
228(2)
7.2 Representative Bulk Nanostructured Metallic Biomaterials
230(15)
7.2.1 Pure Ti
230(5)
7.2.2 Ti Alloys
235(3)
7.2.3 Stainless Steels
238(1)
7.2.4 Co-Cr-Mo Alloy
239(4)
7.2.5 Mg Alloys
243(1)
7.2.6 Pure Fe and Other Fe-Based Alloys
244(1)
7.2.7 Pure Cu
244(1)
7.2.8 Pure Ta
244(1)
7.2.9 Pure Zr
245(1)
7.3 Future Prospect on Bulk Nanostructured Metallic Biomaterials
245(1)
References
246(9)
8 Titanium Implants Based on Additive Manufacture 255(38)
8.1 Introduction
255(1)
8.2 AM Technologies Applicable for Ti-Based Alloys
256(9)
8.2.1 Powder Materials Used in AM Technology
257(1)
8.2.2 Architecture Design in AM Technology
257(2)
8.2.3 Processing Methods of AM Technology
259(4)
8.2.4 Posttreatment of AM Technology
263(1)
8.2.5 Surface Forming Quality of AM Technology
264(1)
8.3 Microstructure and Performance Evaluation of Ti-Based Alloys Fabricated by AM Technology
265(13)
8.3.1 Microstructure of Ti-Based Alloys Fabricated by AM Technology
265(2)
8.3.2 Mechanical Properties of Ti-Based Alloys Fabricated by AM Technology
267(6)
8.3.3 In Vitro Biological Evaluation of Ti-Based Implants Fabricated by AM Technology
273(2)
8.3.4 Animal Experiments of Ti-Based Implants Fabricated by AM Technology
275(2)
8.3.5 Clinical Trials of Ti-Based Implants Fabricated by AM Technology
277(1)
8.4 Prospects
278(7)
References
285(8)
9 Future Research on Revolutionizing Metallic Biomaterials 293(14)
9.1 Tissue Engineering Scaffolds with Revolutionizing Metallic Biomaterials
293(3)
9.2 Building Up of Multifunctions for Revolutionizing Metallic Biomaterials
296(4)
9.3 Intelligentization for Revolutionizing Metallic Biomaterials
300(4)
References
304(3)
Index 307
Yufeng Zheng is Professor in the Department of Materials Science and Engineering at Peking University, China. He started his research career at Harbin Institute of Technology in China after obtained his PhD in materials science there. In 2004, he moved to Peking University and founded the Laboratory of Biomedical Materials and Devices at the College of Engineering. He was a winner of the National Science Fund for Distinguished Young Scholars in 2012. He has published over 360 scientific publications including eight books and seven book chapters.

Xiaoxue Xu is Macquarie University Research Fellow in the Department of Chemistry and Biomolecular Sciences at Macquarie University, Australia. After she received her PhD in Materials Science and Engineering from the University of Western Australia, she worked there as Research Assistant Professor in the School of Chemical and Mechanical Engineering. She joined Macquarie University in 2014 and her research is focused on nanostructured biomaterials.

Zhigang Xu is Senior Research Scientist in Department of Mechanical Engineering at North Carolina A&T State University, USA. He is also affiliated to NSF Engineering Research Center for Revolutionizing Metallic Biomaterials, USA. He received his PhD in Mechanical Engineering from North Carolina A&T State University and then continued his research there as a faculty. He leads a Mg-alloy processing research group and Mg-based alloy design and processing project.

Jun-Qiang Wang is Professor in Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences. He got his PhD in Condensed Matter Physics from Institute of Physics, Chinese Academy of Sciences. From 2010 to 2014 he worked as Research Associate in Tohoku University, Japan and University of Wisconsin-Madison, USA. He joined the Ningbo Institute of Materials Technology & Engineering in 2014 and was awarded the support of One Hundred Talents Program of Chinese Academy of Science. His research focused on fabrication and applications of metallic glasses.

Hong Cai is Associate Professor in Department of Orthopedics at Peking University Third Hospital, China. He worked over 10 years as Attending in orthopedics. During that time he also worked sometime as Clinical Fellow at Seoul University, Korea, University of Western Ontario, Canada and Rush University Medical Center, USA. His research interest is design and development of new implants and 3D printing in orthopedics.