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Principles of Evolutionary Medicine [Kietas viršelis]

4.44/5 (59 ratings by Goodreads)
  • Formatas: Hardback, 312 pages, aukštis x plotis x storis: 246x189x16 mm, weight: 817 g, 80 illustrations
  • Išleidimo metai: 23-Jul-2009
  • Leidėjas: Oxford University Press
  • ISBN-10: 0199236380
  • ISBN-13: 9780199236381
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 312 pages, aukštis x plotis x storis: 246x189x16 mm, weight: 817 g, 80 illustrations
  • Išleidimo metai: 23-Jul-2009
  • Leidėjas: Oxford University Press
  • ISBN-10: 0199236380
  • ISBN-13: 9780199236381
Kitos knygos pagal šią temą:
Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognized as a core underpinning discipline by medical and public health professionals. Advances in the fields of genomics, epigenetics, developmental biology and epidemiology have led to the growing realization that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilize evolutionary biology. It is written in a style which is accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science.

Principles of Evolutionary Medicine is divided into three sections: the first provides a systematic approach to the principles of evolutionary biology as they apply to human health and disease, using examples specifically relevant to medicine. It incorporates chapters on evolutionary processes, molecular evolution, the evolution of humans, life history theory, and evolutionary-developmental biology. The second part illustrates the application of these principles to our understanding of nutrition and metabolism, reproduction, combating infectious disease and stress, and human behavior. The final section provides a general framework to show in practical terms how the principles of evolutionary medicine can be applied in medical practice and public health.

This novel textbook provides the necessary toolkit for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.

Recenzijos

How often has anyone said after reading a textbook, "Wow, what a great read!"? That is what I just did. Peter Gluckman, along with Alan Beedle and Mark Hanson, have written a wonderful introduction to the principles of evolutionary biology and defined ways in which these principles can be applied to understanding human disease. Books and Media Reviews Section Editor, JAMA [ The book is] clearly written and wonderfully organized. [ It] brings students to a point where they can meaningfully engage in debates on the issues at a fairly sophisticated level. SCIENCE

Preface xiii
Part 1 Fundamentals of Evolutionary Biology
Introduction
3(18)
What is disease?
4(4)
What evolution is: Fundamental principles
8(5)
Selection
10(1)
Variation and inheritance
10(1)
Development and the life course
11(2)
Time
13(2)
Constraints
15(1)
We Are not alone
15(2)
How evolutionary arguments fit alongside other biological perspectives
17(1)
Evolution and medicine
18(3)
Key points
18(1)
Further reading
18(3)
Evolutionary theory
21(30)
Introduction
21(5)
What does evolutionary theory explain?
26(3)
How does evolution work?
29(12)
Variation
30(1)
Mutation
31(1)
Recombination
31(1)
Constraints on variation
32(2)
Selection
34(1)
Artificial selection
34(1)
Natural selection
34(1)
Sexual selection
35(1)
Levels of selection
36(1)
Genes as units of selection
37(1)
Extended phenotype
38(1)
Inheritance
38(3)
Areas of debate and the limitations of adaptationist argument
41(7)
Does evolution have a direction?
41(1)
Selection is not random
42(1)
Is selection the only mechanism of evolution?
43(1)
Is every feature of an organism an adaptation?
44(1)
How do species evolve?
45(2)
How fast is evolution?
47(1)
How do we explain traits that appear to reduce fitness?
48(1)
Conclusion
48(3)
Key points
49(1)
Further reading
49(2)
The molecular basis of variation and inheritance
51(26)
Introduction
51(1)
Molecular basis of human genetic variation
52(5)
What is a gene?
52(1)
Mutation as a cause of sequence variation in the genome
53(1)
SNPs
53(3)
Indels
56(1)
VNTRs
56(1)
Transposable elements
56(1)
Structural polymorphism
57(1)
How different are any tow individual genomes?
57(3)
Recombination as a source of variation
58(1)
Haplotypes and linkage
59(1)
Factors affecting variation
60(4)
How drift affects diversity
60(3)
Molecular effects of selection
63(1)
Signatures of selection
64(1)
From genotype to phenotype
64(4)
Why hasn't selection eliminated monogenic disease from the population?
68(2)
No single genes for common diseases
70(1)
Non-genetic inheritance
71(3)
Conclusion
74(3)
Key points
74(1)
Further reading
75(2)
Evolution and development
77(20)
Introduction
77(2)
Development: pre-ordained or plastic?
79(1)
Is development important?
80(3)
Developmental plasticity
83(1)
Responses to environmental cues during development
84(4)
Developmental disruption
84(1)
Adaptive responses in development
85(1)
Immediately adaptive responses: coping with the consequences
85(1)
Predictive adaptive responses
86(2)
Epigenetic mechanisms
88(2)
Intergenerational effects
90(2)
Learning and instinct
92(1)
Evolution of novelty
92(2)
Conclusion
94(3)
Key points
96(1)
Further reading
96(1)
Evolution of life histories
97(26)
Introduction
97(1)
General overview of life history theory
98(10)
Key trade-offs in life histories
98(2)
Number versus quality of offspring
100(1)
Current versus future reproduction
100(1)
Age versus size at maturity
101(1)
Fecundity versus lifespon
101(1)
Extrinsic and intrinsic mortality
102(2)
Extrinsic mortality and age at menarche
104(1)
Lifespan and ageing
105(1)
Evolutionary theories of senescence
106(2)
Body size and shape
108(4)
Allometry
109(1)
Variation in growth and development
109(3)
Growth in humans
112(4)
Phases of growth
112(2)
Puberty
114(2)
Evolutionary analysis of the distinct features of human growth
116(4)
The Childhood phase
117(1)
Pubertal growth spurt
118(1)
Reproductive decline and the menopause
119(1)
Conclusion: interpreting the human life history
120(3)
Key points
121(1)
Further reading
121(2)
Human evolution and the origins of human diversity
123(28)
Introduction
123(1)
The hominoid clade
123(1)
Hominin evolution
124(17)
Timeline and species
124(3)
Bipedalism
127(1)
Body size
128(1)
Face, jaw, and dentition
128(1)
Gastrointestinal tract
129(1)
The hairless ape
129(1)
The hominin brain
129(5)
Tool making
134(1)
Language
135(2)
Culture and society
137(2)
Cultural evolution
139(2)
Human adaptation to local selection pressures
141(3)
Hominin origins and migrations: out of Africa again
141(2)
Variation caused by migration
143(1)
Variation caused by change in lifeways
144(1)
Are humans still evolving?
144(2)
Social implications of human diversity
146(1)
Conclusion
147(4)
Key points
147(1)
Further reading
147(4)
Part 2 Understanding Human Disease From an Evolutionary Perspective
Reproduction
151(28)
Introduction
151(1)
Sexual reproduction
152(1)
Why did sex evolve?
152(3)
Sex determination
155(1)
Reproductive strategies
155(1)
Mate choice
156(4)
Sexual differences in the human
160(1)
Gender differences in morbidity and mortality
161(1)
The human reproductive cycle
162(13)
Puberty
162(1)
The timing of puberty
163(3)
Why menstruate?
166(1)
Pregnancy
166(1)
The Placenta
167(1)
Maternal-fetal interactions
168(2)
Regulation of fetal growth
170(2)
Conflict in development
172(1)
Lactation and postnatal care
172(1)
The menopause
173(2)
Conclusion: reproduction and evolution
175(4)
Key points
176(1)
Further reading
177(2)
Nutritional and metabolic adaptation
179(32)
Introduction
179(1)
Strategies for energy storage
179(3)
Human diet: an evolutionary history
182(10)
Pre-agricultural hominins
182(1)
Anatomical evidence for diet quality in early humans
183(1)
Modern foraging populations: what do they teach us?
184(2)
The Neolithic Revolution
186(1)
The modern nutrition transition
187(1)
Well fed but poorly nourished
188(4)
How can change in the environment increase disease risk?
192(5)
A `thrifty' genotype?
192(1)
Search for thrifty genes
192(2)
Was there feast and famine?
194(1)
Has post-agricultural famine selected thrifty genes?
194(3)
Does evolutionary novelty explain current patterns of metabolic disease and obesity?
197(1)
A developmental perspective: the missing link?
198(8)
Maladaptive consequences of an adaptive process
201(2)
Developmental platicity in the setting of evolutionary novelty
203(2)
Other possible developmental pathways
205(1)
Conclusion
206(5)
Key Points
208(1)
Further reading
208(3)
Defence
211(22)
Introduction
211(1)
Predation and conspecific violence
211(5)
Stress
212(1)
Developmental changes in stress responses: adaptive prediction
213(3)
Dealing with infection
216(12)
Commensals
216(1)
Pathogen emergence
217(1)
Virulence
218(3)
Antibiotic resistance
221(1)
Microbiota and the human genome
221(1)
Innate immunity
222(2)
Adaptive immunity
224(2)
Vaccination
226(1)
Dysregulation of the immune system
227(1)
Autoimmune disease
227(1)
Developmental regulation of immunity
227(1)
Allergies and chronic inflammatory disorders
227(1)
Other threats
228(1)
Injury
229(1)
Sleep and repair
230(1)
Conclusion
230(3)
Key points
231(1)
Further reading
231(1)
Stress responses
231(1)
Defence
231(1)
Detoxification
231(2)
Social organization and behaviour
233(24)
Introduction
233(1)
Biological determinants of culture and behaviour
233(1)
Evolution of human brain and behaviour
234(2)
Evolution of social behaviour
236(10)
Altruism
237(2)
Selfishness and selfish genes
239(3)
Emotions: Darwinian algorithms of the mind
242(1)
Love, jealousy, marriage, and inheritance
242(2)
Group behaviour and morality
244(1)
Belief and religion
244(1)
Learning
245(1)
Evolutionary perspectives on psychology
246(2)
Evolutionary psychiatry
248(3)
Personality traits and disorders
248(1)
Disorders of mood
249(1)
Anxiety
249(1)
Phobias
249(1)
Depression and bipolar disorder
250(1)
Psychoses
251(1)
Conclusion
251(6)
Key Points
253(1)
Further reading
253(4)
Part 3 An Evolutionary Framework for Health and Disease
Evolutionary principles applied to medical practice
257(20)
Introduction
257(1)
Fundamental principles of evolutionary medicine
258(1)
Why has evolution left our bodies vulnerable to disease?
259(1)
An evolutionary classification of ultimate mechanisms affecting disease risk
260(8)
an evolutionarily mismatched or novel environment
260(3)
life history-associated factors
263(1)
excessive and uncontrolled defence mechanisms
264(1)
losing the evolutionary arms race
264(1)
results of evolutionary constraints
265(1)
an apparently harmful allele is maintained by balancing selection
266(1)
sexual selection and competition and their consequences
266(1)
the outcomes of demographic history
267(1)
Cultural evolution and disease
268(1)
Evolutionary perspectives and cancer
268(4)
Evolutionarily novel environments and cancer
269(1)
Relationships to life history traits
270(1)
Cancer and the evolutionary arms race
271(1)
Demographic history
271(1)
Understanding disease from an evolutionary perspective
272(1)
The medical history
272(1)
An evolutionary evaluation of clinical signs and symptoms
272(1)
Implications for prevention and therapy
273(1)
The challenges of an evolutionary perspective in medicine
274(1)
Conclusion
275(2)
Key points
275(1)
Further reading
276(1)
Coda: evolution, medicine, and society
277(6)
Society and evolution
277(2)
Religion and evolution
279(1)
Social Darwinism, eugenics, and political thought
279(2)
Research directions
281(1)
The future of Homo sapiens
281(2)
Further reading
282(1)
Index 283
Dr Alan S. Beedle is Research Fellow at the Liggins Institute, University of Auckland. He is a biochemist who became a professional science editor and writer. He has held senior positions in scientific and medical publishing in the UK, Europe and New Zealand, and has been editor of several high-impact journals in the biomedical sciences. Alan advises members of the Institute on publication strategy, and also has research interests in the application of evolutionary and developmental biology to human health and disease.