El. knyga: Toxicology of the Kidney

The third edition of this reference provides a thorough overview of current research in the field, with particular attention to developments since the second edition was published in 1993. New to this edition are chapters on the clinical aspects of nephrotoxicity and information concerning risk assessment and expanded treatment of topics that include in vitro models, the mechanisms of cell injury and of signaling pathways, and biomarkers of renal disease. Each chapter concludes with an exhaustive bibliography. The chapter titles include role of xenobiotic metabolism, the role of endocytosis in nephrotoxicity, adhesion molecules in renal physiology and pathology, analgesics and non-steroidal anti-inflammatory drugs, and mycotoxins affecting the kidney. Lash teaches pharmacology at Wayne State U. in Detroit; Tarloff teaches pharmacology and toxicology at the Philadelphia College of Pharmacy, U. of the Sciences. Specialists in the US and Europe are the contributors. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Updated to reflect the latest research in the field, Toxicology of the Kidney, Third Edition focuses on the correlation between the anatomy, biochemistry, and physiology of the kidney. The text seeks to explain how this correlation is related to concepts of clinical nephrotoxicity, and renal failure in humans and how animal models can be used to understand the mechanisms of human renal disease.