Insect transgenesis promises improvements in agriculture, pharmaceuticals and public health. Many important insects can now be routinely transformed with effectors that have useful applications. Agriculture presents the largest market for transgenic insects and has a foundational history of success with sterile insect technique for control of pests including Mediterranean fruit flies and screwworms. Biotechnology will contribute superior markers, suppressible sterility and sex-conversion. Public health is also seeing transgenic mosquitoes developed which suppress natural populations and are incapable of transmitting disease. Experts in the field contribute their insights into the latest technology and its applications. The authors also consider the larger risks, social and economic aspects of transgenic insects whose value must be proven in political, regulatory and public acceptance arenas.
Insect transgenesis promises improvements in agriculture, pharmaceuticals and public health. Many important insects can now be routinely transformed with effectors that have useful applications. Agriculture presents the largest market for transgenic insects and has a foundational history of success with sterile insect technique for control of pests including Mediterranean fruit flies and screwworms. Biotechnology will contribute superior markers, suppressible sterility and sex-conversion. Public health is also seeing transgenic mosquitoes developed which suppress natural populations and are incapable of transmitting disease. Experts in the field will contribute their insights into the latest technology and its applications. Authors will also consider the larger risks, social and economic aspects of transgenic insects whose value must be proven in political, regulatory and public acceptance arenas.
PART 1: GERMLINE TRANSFORMATION TECHNOLOGY 1: Transposons for
Insect Transformation David A. OBrochta, Kasim George and Hanfu Xu 2:
Transposon-Based Technologies for Insects David A. OBrochta, Kasim George
and Hanfu Xu 3: Sex-, Tissue- and Stage-Specific Transgene
Expression Andrew Marc Hammond and Tony Nolan 4: Docking Systems for
Site-Directed Transgene Integration Paul Eggleston and Janet M. Meredith 5:
Inducible and Repressible Systems for Transgene Expression Rosemary S.
Lees, Rocco DAmato and Mark Q. Benedict 6: Sex Ratio Manipulation for
Insect Population Control Philippos A. Papathanos, Nikolai Windbichler and
Omar S. Akbari 7: Conditional Dominant Lethals RIDL Luke Alphey,
Martha Koukidou and Neil I. Morrison PART 2: APPLICATIONS OF TRANSGENIC
INSECTS 8: Tephritid Fruit Fly Transgenesis and Applications Alfred M.
Handler and Marc F. Schetelig 9: Silkworm Transgenesis and
Applications Hideki Sezutsu and Toshiki Tamura 10: Transgenic Approaches
for Sterile Insect Control of Dipteran Livestock Pests and Lepidopteran Crop
Pests Maxwell J. Scott, Neil I. Morrison and Gregory S. Simmons 11:
Antipathogen Effector Molecules: Current and Future Strategies Michael A.
Riehle and Shirley Luckhart 12: Sexual Sterilization of Mosquitoes Paolo
Gabrieli, Eric Marois and Flaminia Catteruccia PART 3: ALTERNATIVE TRANSGENIC
APPROACHES TO MODIFYING INSECT PHENOTYPES 13: Paratransgenesis in
Mosquitoes and Other Insects: Microbial Ecology and Bacterial Genetic
Considerations David J. Lampe and Nicholas J. Bongio 14: Asaia
Paratransgenesis in Mosquitoes Guido Favia 15: Paratransgenic Control of
Chagas Disease Ivy Hurwitz, Nicole Klein, Adam P. Forshaw and Ravi V.
Durvasula 16: Tsetse Paratransgenesis: a Novel Strategy for Reducing the
Spread of African Trypanosomiasis Brian L. Weiss and Serap Aksoy PART 4:
CONSIDERATIONS FOR THE RELEASE OF TRANSGENIC INSECTS 17: RIDL: Modelling
Release of Insects Carrying a Dominant Lethal Nina Alphey and Michael B.
Bonsall 18: Assessing Risk of Transgenic Insects M.M. Quinlan 19:
Economics of Transgenic Insects for Field Release John D. Mumford and L.
Roman Carrasco 20: Risk Analysis and the Regulation of Transgenic
Insects Camilla Beech and Tom Miller 21: Public Acceptability of New
Insect Vector Control Technologies Katherine F. King, Pamela Kolopack, Lara
Zahabi-Bekdash and James V. Lavery 22: The Cartagena Protocol on the
Transboundary Movement of Living Modified Organisms: The Regulation of Trade
in Transgenic Organisms under International and European Environmental
Law Ricardo Pereira
Mark has a PhD in entomology with an emphasis on molecular biology and genetics from the University of Florida. He has been a developer of technology for developing transgenic insects, developed insectary methods for producing mosquitoes for release into the field, directed field studies underlying releases of transgenic insects and assisting developing country operations where transgenic insects will be used. He has worked at USDA, the Centers for Disease Control and Prevention (CDC), the International Atomic Energy Agency and the University of Perugia. He is currently a research biologist at the CDC and is based in Atlanta, GA USA. He has contributed book chapters and over 100 peer reviewed publications.
